CLINICOPATHOLOGICAL DIFFERENCES BETWEEN RIGHT-SIDED AND LEFT-SIDED COLON CANCERS

Comparative molecular analyses of left-sided colon, right-sided colon, and rectal cancers

Tumor sidedness has emerged as an important prognostic and predictive factor in the treatment of colorectal cancer. Recent studies demonstrate that patients with advanced right-sided colon cancers have a worse prognosis than those with left-sided colon or rectal cancers, and these patient subgroups respond differently to biological therapies. Historically, management of patients with metastatic...

Laterality: Right-Sided and Left-Sided Colon Cancer

Colorectal cancer (CRC) can be characterized by the location of the primary tumor being within the colon [1]. Right-sided colon cancer (RCC) is derived from the embryologic midgut, including the proximal two-thirds of the transverse colon, ascending colon, and cecum. Left-sided colon cancer (LCC) is derived from the embryologic hindgut, which includes the distal third of the transverse colon, s...

Right-sided colon cancer and left-sided colorectal cancers respond differently to cetuximab.

INTRODUCTION Right-sided colon cancer (RSCC) and left-sided colorectal cancer (LSCRC) differ with respect to their biology and genomic patterns. This study aimed to examine whether the primary tumor location is associated with the response to cetuximab in patients with metastatic colorectal cancer (mCRC). METHODS Patients with mCRC treated with cetuximab and standard chemotherapy as first- or...

Identification of genomic expression differences between right-sided and left-sided colon cancer based on bioinformatics analysis

Introduction More and more findings have demonstrated that right-sided colon cancers (RCC) and left-sided colon cancers (LCC) are distinct clinical and biological entities and suggest that they should be treated as different diseases. However, the reasons why RCC and LCC harbor different clinical and biological features remain unclear. Materials and methods To identify the genomic expression ...

Valve site-specific pathogenetic differences between right-sided and left-sided bacterial endocarditis.